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Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Colchicine may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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more potent than Colchicine in producing analgesia and 200 times more potent in ?-opioid binding.
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Other medicines´┐ŻAlthough certain medicines should not be used together at all,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Colchicine is rapidly and almost completely absorbed after oral administration.
Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
the drug are not limited to those patients with prior history of opioid dependence.
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In an open randomized trial, rectal Colchicine was compared with our standard treatment acetaminophen/codeine suppositories. We expected Colchicine to be equally effective as our current standard but with fewer side effects.
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Forty patients were treated with either Colchicine suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Colchicine 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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Colchicine has not been shown to cause histamine release. At therapeutic doses, Colchicine has no effect on heart rate, left-ventricular function or cardiac index.
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If you suddenly stop taking Colchicine , you may experience WITHDRAWAL symptoms including anxiety;
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No effects on fertility were observed for Colchicine at oral dose levels up to 50 mg/kg,
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Colchicine is associated with craving and tolerance development.
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Colchicine is administered as a racemate and both [-] and [+] forms of both Colchicine and M1 are detected in the circulation.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Colchicine may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Colchicine has not been shown to cause histamine release.
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Talk with your doctor if Colchicine stops working well. Do not take more than prescribed.Some people who use Colchicine for a long time without a break may develop a physical need to continue taking it.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Colchicine and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Talk with your doctor if Colchicine stops working well. Do not take more than prescribed.Some people who use Colchicine for a long time without a break may develop a physical need to continue taking it.
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This effect may go away if you lie down forawile.
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For Colchicine, the following should be considered:The suitability of Colchicine suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Colchicine group.
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Do not use this medication if you are allergic,
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Forty patients were treated with either Colchicine suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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more potent than Colchicine in producing analgesia and 200 times more potent in ?-opioid binding.
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Colchicine may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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A single i.m. dose of Colchicine is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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risk of discontinuation due to adverse events associated with higher initial doses,
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Colchicine is administered as a racemate and both [-] and [+] forms of both Colchicine and M1 are detected in the circulation.
Respiratory depression should be treated as an overdose.
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